Inflammatory bowel disease and drug-induced liver damage

The article presents the results of a review publications devoted to study problems drug-induced liver damage in inflammatory bowel diseases (IBD). hepatotoxic effect thiopurines (azathioprine and 6-mercaptopurine) — hepatotoxicity from 0% 17%; sulfasalazine mesalamine (hepatotoxicity 4%); methotrexate 15% 50%); tumor necrosis factor inhibitors up 75% cases.), anti-integrins 2% 5%); an interleukin 12/23 inhibitor 0,5% 2%); Janus-kinase is considered 1% 2%). Conclusion . drugs currently used treat IBD require periodic function tests rule out lesions that therapy correction. As range new rapidly expanding, this requires special observation discussion terms their adverse effects on liver.